General Information

  • ID:  hor000333
  • Uniprot ID:  Q94742
  • Protein name:  Allatostatin-2
  • Gene name:  NA
  • Organism:  Schistocerca gregaria (Desert locust) (Gryllus gregarius)
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Schistocerca (genus), Cyrtacanthacridinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  AYTYVSEYKRLPVYNFGL
  • Length:  18(93-110)
  • Propeptide:  MGMTSRSSSSEAARLPLPALVLLLLCTSPATPQEVPGDAMTGGGPASAPVSTASEAAAASPPGSASTGAAPMDAESEYDLYKRLCDFGVGKRAYTYVSEYKRLPVYNFGLGKRATGAASLYSFGLGKRGPRTYSFGLGKRGDDEPNDYSEQELFADVDGDSEDALPVAVEADERELPEAAEEEMPGVFTELMDKRGRLYSFGLGKRARPYSFGLGKRAGPAPSRLYSFGLGKREGRMYSFGLGKRPLYGGDRRFS
  • Signal peptide:  MGMTSRSSSSEAARLPLPALVLLLLCTSPATP
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  It show potent inhibitory effects on juvenile hormone (JH) biosynthesis by corpora allata (CA) of the cockroach Diploptera punctata
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q94742-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000333_AF2.pdbhor000333_ESM.pdb

Physical Information

Mass: 248688 Formula: C105H151N23O28
Absent amino acids: CDHIMQW Common amino acids: Y
pI: 8.98 Basic residues: 2
Polar residues: 8 Hydrophobic residues: 6
Hydrophobicity: -19.44 Boman Index: -1680
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 81.11
Instability Index: 4240 Extinction Coefficient cystines: 5960
Absorbance 280nm: 350.59

Literature

  • PubMed ID:  8902848
  • Title:  Isolation and Characterization of Eight Myoinhibiting Peptides From the Desert Locust, Schistocerca Gregaria: New Members of the Cockroach Allatostatin Family